A breakthrough in Mental Health: Ketamine therapy
Our brain can adapt and evolve based on our environment; a phenomenon called neuroplasticity. Genetic predisposition combined with environmental factors such as constant exposure to stress can decrease the neuroplasticity of our brain; paving the way to various mental health conditions such as depression. Unfortunately, more than one third of patients will not respond to conventional treatment modalities for depression.
How does it exactly work?
Ketamine works completely different than conventional psychotropic medications that it acts directly to restore neuroplasticity by creating new pathways in our brain critical to emotional regulation and healthy thought process. Ketamine acts like a sophisticated fertilize of our brain. It accomplishes that by blocking the NMDA receptor in our brain which then causes a surge of a neurotransmitter called glutamate. The surge in glutamate stimulates AMPA receptors causing the release of growth factors like the brain-derived neurotrophic factor (BNDF) which ultimately results into dendritic spine formation (neural pathways). The increase in synaptic connections is associated with enhanced neuroplasticity in our brain paving the way to healthier thought patterns and emotional regulation.
A systematic review and meta-analyses of 83 high-quality studies support ketamine as a robust, quick, and transient antidepressant agent.
High-quality analyses supports ketamine as a widely effective and sustained treatment for treatment-resistant anxiety spectrum disorders.
High-quality evidence showing efficacy of repeated ketamine infusions in decreasing severity of chronic PTSD symptoms.
Meta-analysis showing the swift and strong anti-depressant effects of single-dose ketamine in patients with treatment-resistant depression.